JOURNAL ARTICLE
REVIEW

Blood vessel formation and function in bone

Kishor K Sivaraj, Ralf H Adams
Development 2016 August 1, 143 (15): 2706-15
27486231
In addition to their conventional role as a conduit system for gases, nutrients, waste products or cells, blood vessels in the skeletal system play active roles in controlling multiple aspects of bone formation and provide niches for hematopoietic stem cells that reside within the bone marrow. In addition, recent studies have highlighted roles for blood vessels during bone healing. Here, we provide an overview of the architecture of the bone vasculature and discuss how blood vessels form within bone, how their formation is modulated, and how they function during development and fracture repair.

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