125 Transorbital Ultrasound Measurement as a Noninvasive Marker of Intracranial Pressure.

INTRODUCTION: Reliable assessment of intracranial pressure (ICP) remains crucial in managing neurosurgical conditions in children. The present study examined the relationship between transorbital ultrasound measurement of the optic nerve sheath diameter (ONSD) and invasively measured ICP in children.

METHODS: This was a prospective, observational study comparing ONSD measurement with invasive ICP measurement. All patients were under general anesthesia and physiological variables, including systolic and diastolic blood pressure, mean arterial pressure, pulse rate, temperature, respiratory rate, and end-tidal carbon dioxide level, were recorded at the time of ONSD measurement. The ONSD measurements were analyzed for intra- and interobserver variability. The diagnostic accuracy of ONSD measurement for detecting ICP at thresholds of 20, 15, 10, and 5 mm Hg was analyzed, including evaluation of age-related thresholds in children.

RESULTS: One hundred ninety-six children were evaluated. The median age was 36 months (interquartile range, 8-82). Etiology included, hydrocephalus (52.9%), traumatic brain injury (17.2%), tumor (9.2%), craniosynostosis (9.2%), cystic malformation (6.9%), other (4.6%). ONSD measurement demonstrated good correlation with ICP across the entire patient cohort (r = 0.66, P < .001), but was better in children >1 year or with a closed anterior fontanelle (AF) (r = 0.7, P < .001). The ONSD values with the best diagnostic accuracy for detecting ICP above 20 mm Hg in older children was 5.75 mm, with a sensitivity of 85.9%, specificity of 70.4%, positive predictive value of 77.5%, negative predictive value of 80.9%, and area under the receiver operating characteristic of 0.78. The diagnostic odds ratio was 14.5. Diagnostic testing was performed at ICP thresholds of 15, 10, and 5 mm Hg as well.

CONCLUSION: Measurement of the ONSD is a sensitive surrogate marker of raised ICP with limited specificity. This relationship was more reliable in older children, particularly when the AF was closed. This study provides the first data supporting the relationship between ONSD measurement and invasively measured ICP at various thresholds.