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Journal Article
Research Support, Non-U.S. Gov't
Distribution and Developmental Changes of Neuropeptide Y and Its Y1 Receptor-like Immunoreactive Cells in the Duck Thymus.
OBJECTIVE: To investigate the distribution and developmental changes of Neuropeptide-Y (NPY) and its Y1 receptor (NPYY1)-like immunoreactivity cells in the duck thymus using immunohistochemistry associated with morphological analysis.
STUDY DESIGN: Studies were carried out on Tianfu ducks on days 14, 18, 22, and 26 of embryogenesis (E14, E18, E22, and E26) as well as at 0 (neonatal stage), 1, 3, 5, 8, 11, 14, 17, 20, 26, 29, and 32 weeks of postnatal development (P0, P1, P3, P5, P8, P11, P14, P17, P20, P26, P29, and P32).
RESULTS: NPY-like immunoreactivity (NPY-ir) was detected mainly in the epithelial reticular cells and vascular smooth muscles, slightly in the lymphocytes from E26 onwards. On E26, NPY-ir was restricted to the epithelial reticular cells of diffuse forms of Hassall's corpuscle (DHC). The integral optical density (IOD) values of NPY-ir cells in the cortex and medulla did not significantly change from P0 to P17, but then dramatically rose from P20 to P32. NPYY1-like immunoreactivity (NPYY1-ir) was observed mainly in the lymphocytes, slightly in the epithelial reticular cells of DHC and the vascular smooth muscles from E18 onwards. The IOD values of NPYY1-ir cells significantly increased from E18 to E22, then kept unchanged until P0, greatly increased on P3, and then remained stable until P17 but dramatically increased from P20 to P32.
CONCLUSION: These results suggest that the possible interaction between NPY and NPYY1 may take place within the duck thymus chiefly during postembryonic development, which might be of great importance for the function of thymocytes, as well as duck thymus involution.
STUDY DESIGN: Studies were carried out on Tianfu ducks on days 14, 18, 22, and 26 of embryogenesis (E14, E18, E22, and E26) as well as at 0 (neonatal stage), 1, 3, 5, 8, 11, 14, 17, 20, 26, 29, and 32 weeks of postnatal development (P0, P1, P3, P5, P8, P11, P14, P17, P20, P26, P29, and P32).
RESULTS: NPY-like immunoreactivity (NPY-ir) was detected mainly in the epithelial reticular cells and vascular smooth muscles, slightly in the lymphocytes from E26 onwards. On E26, NPY-ir was restricted to the epithelial reticular cells of diffuse forms of Hassall's corpuscle (DHC). The integral optical density (IOD) values of NPY-ir cells in the cortex and medulla did not significantly change from P0 to P17, but then dramatically rose from P20 to P32. NPYY1-like immunoreactivity (NPYY1-ir) was observed mainly in the lymphocytes, slightly in the epithelial reticular cells of DHC and the vascular smooth muscles from E18 onwards. The IOD values of NPYY1-ir cells significantly increased from E18 to E22, then kept unchanged until P0, greatly increased on P3, and then remained stable until P17 but dramatically increased from P20 to P32.
CONCLUSION: These results suggest that the possible interaction between NPY and NPYY1 may take place within the duck thymus chiefly during postembryonic development, which might be of great importance for the function of thymocytes, as well as duck thymus involution.
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