JOURNAL ARTICLE
REVIEW

CTCF and Cohesin in Genome Folding and Transcriptional Gene Regulation

Matthias Merkenschlager, Elphège P Nora
Annual Review of Genomics and Human Genetics 2016 August 31, 17: 17-43
27089971
Genome function, replication, integrity, and propagation rely on the dynamic structural organization of chromosomes during the cell cycle. Genome folding in interphase provides regulatory segmentation for appropriate transcriptional control, facilitates ordered genome replication, and contributes to genome integrity by limiting illegitimate recombination. Here, we review recent high-resolution chromosome conformation capture and functional studies that have informed models of the spatial and regulatory compartmentalization of mammalian genomes, and discuss mechanistic models for how CTCF and cohesin control the functional architecture of mammalian chromosomes.

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