JOURNAL ARTICLE
REVIEW

Hyponatremia in cancer patients: Time for a new approach

Rossana Berardi, Silvia Rinaldi, Miriam Caramanti, Christian Grohè, Matteo Santoni, Francesca Morgese, Mariangela Torniai, Agnese Savini, Ilaria Fiordoliva, Stefano Cascinu
Critical Reviews in Oncology/hematology 2016, 102: 15-25
27066939
Hyponatremia is a common electrolyte disorder in cancer patients. It may be related to cancer, to anti-cancer therapy or to other concomitant treatments. In this setting hyponatremia is often caused by the syndrome of inappropriate anti-diuretic hormone secretion, which is due to the ectopic production of antidiuretic hormone (vasopressin), to extracellular fluid depletion, to renal toxicity caused by chemotherapy or to other underlying conditions. Recent studies suggested that hyponatremia might be considered a negative prognostic factor for cancer patients therefore its early detection, monitoring and management might improve the patient's outcome. Treatment of hyponatremia depends on patient's symptoms severity, onset timing and extracellular volume status. In this review we summarize the main causes of hyponatremia in cancer patients and its management, including the available treatment options.

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