Prevalence of Cognitive Disorders in Patients with Systemic Lupus Erythromatosus; a Cross-sectional Study in Rasoul-e-Akram Hospital, Tehran, Iran

Aliyeh Mahdavi Adeli, Anousheh Haghighi, Seyed Kazem Malakouti
Archives of Iranian Medicine 2016, 19 (4): 257-61

BACKGROUND: Neuropsychological manifestations are present in 60% of patients with Systemic Lupus Erythematosus (SLE) among which cognitive dysfunction is the most common. This study aims to determine the prevalence of cognitive disorders in SLE patients, and the relationship between cognitive disorder domains and depression and anxiety.

METHODS: In this cross-sectional study, 54 patients with SLE and 48 healthy subjects were included. Mini-Mental State Examination (MMSE), Clock Drawing Test (CDT) and Trail Making Test part A (TMT-A) were used to screen for cognitive impairments. All subjects were evaluated with the Beck Depression Inventory (BDI) and the Beck Anxiety Inventory (BAI) to determine depression and anxiety as probable confounding variables.

RESULTS: The mean MMSE scores in SLE and control group patients (26.12 ± 3.58 and 28.01 ± 1.99, respectively) were significantly different (P = 0.001). The sub-scores in all areas assessed with MMSE were lower in SLE patients; however, it was only significant in the areas of orientation, recall and language (P < 0.05). SLE patients showed a significantly poorer performance in TMT compared to healthy controls (P = 0.01). The CDT according to the Watson scoring system showed significant difference between the two groups (P = 0.03). The Sunderland scoring system also indicated poorer performance in the SLE group, but the difference was not significant.

CONCLUSION: Our study showed that cognitive disorders are more than 3-fold higher in SLE patients compared to normal subjects. The most impaired domains include orientation, Memory (recall), Language, Executive function, and psychomotor speed. Anxiety and depression are mostly correlated with domains included in the MMSE test.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"