JOURNAL ARTICLE
REVIEW

Congenital varicella syndrome: A systematic review

Ki Hoon Ahn, Yun-Jung Park, Soon-Cheol Hong, Eun Hee Lee, Ji-Sung Lee, Min-Jeong Oh, Hai-Joong Kim
Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology 2016, 36 (5): 563-6
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Varicella-zoster virus (VZV) is a teratogen that can cross the placenta and cause the congenital varicella syndrome (CVS), which is characterised by multi-system anomalies. There have been 130 reported cases of CVS from 1947 to 2013. The estimated incidence of CVS was 0.59% and 0.84% for women infected with VZV during the entire pregnancy and for those infected the first 20 weeks of pregnancy, respectively. Nine cases were reported at 21-27 weeks of gestation and one case was identified at 36 weeks. Herpes zoster caused CVS in two cases. Regarding treatment, varicella zoster immunoglobulin treatment, irrespective of gestational age, should be considered in addition to antiviral drugs for women who have been exposed to or infected with virus.

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