Treatment of Xanthelasma Palpebrarum With Intralesional Pingyangmycin

Hui Wang, Yingshen Shi, Huapeng Guan, Caiyue Liu, Wenjun Zhang, Yingfan Zhang, Antang Liu, Yuxin Qian, Yaozhong Zhao, Hua Jiang
Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.] 2016, 42 (3): 368-76

BACKGROUND: Xanthelasma palpebrarum (xanthelasma) is the most common type of cutaneous xanthoma, and many patients tend to seek medical treatments for cosmetic reasons. Many methods treating xanthelasma have been proposed, but none of these options can be regarded as a perfect solution.

OBJECTIVE: To study and evaluate the intralesional injection treatment of xanthelasma with pingyangmycin, which has been widely used as a broad-spectrum antitumor antibiotic.

MATERIALS AND METHODS: 21 lesions in 12 patients were treated by intralesional pingyangmycin. Photographs were taken before and after each treatment session. Patients were followed up for 7 to 36 months.

RESULTS: All patients except one received satisfactory results after up to 2 sessions. Only 1 patient had a local recurrence 1 year after the treatment. No severe complications such as infection, atrophy, ulceration, or scar were noticed.

CONCLUSION: Intralesional pingyangmycin is a cheap, effective, and safe treatment for xanthelasma, which has been well accepted by patients.

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