Probing Protein Surfaces: QSAR Analysis with Helix Mimetics

Valeria Azzarito, Philip Rowell, Anna Barnard, Thomas A Edwards, Andrew Macdonald, Stuart L Warriner, Andrew J Wilson
Chembiochem: a European Journal of Chemical Biology 2016 April 15, 17 (8): 768-73
α-Helix-mediated protein-protein interactions (PPIs) are important targets for small-molecule inhibition; however, generic approaches to inhibitor design are in their infancy and would benefit from QSAR analyses to rationalise the noncovalent basis of molecular recognition by designed ligands. Using a helix mimetic based on an oligoamide scaffold, we have exploited the power of a modular synthesis to access compounds that can readily be used to understand the noncovalent determinants of hDM2 recognition by this series of cell-active p53/hDM2 inhibitors.

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