Endocrinopathies induced by immune-checkpoint inhibitors in advanced non-small cell lung cancer

Emanuela Rossi, Assunta Sgambato, Giovanni De Chiara, Francesca Casaluce, Tania Losanno, Paola Claudia Sacco, Giuseppe Santabarbara, Cesare Gridelli
Expert Review of Clinical Pharmacology 2016, 9 (3): 419-28
The advent of immunotherapy has recently expanded the therapeutic options in advanced non-small cell lung cancer (NSCLC). In these patients, the recent efficacy demonstration of antibodies against immune checkpoints: the anti-programmed death-1 (PD-1) and anti-programmed death ligand-1 (PD-L1), has led to approval of nivolumab and pembrolizumab (anti-PD-1) in the treatment of advanced NSCLC. The mechanism of action of checkpoint inhibitors explains the development of autoimmune diseases as a side-effect of these medications. Among these, a spectrum of endocrine disorders has been also reported. This manuscript focuses particularly on endocrine disorders induced by immuno-checkpoint inhibitors employed in NSCLC, in order to suggest the strategies for their diagnosis and effective management.

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