Association of Coffee Consumption With Total and Cause-Specific Mortality in 3 Large Prospective Cohorts

Ming Ding, Ambika Satija, Shilpa N Bhupathiraju, Yang Hu, Qi Sun, Jiali Han, Esther Lopez-Garcia, Walter Willett, Rob M van Dam, Frank B Hu
Circulation 2015 December 15, 132 (24): 2305-15

BACKGROUND: The association between consumption of caffeinated and decaffeinated coffee and risk of mortality remains inconclusive.

METHODS AND RESULTS: We examined the associations of consumption of total, caffeinated, and decaffeinated coffee with risk of subsequent total and cause-specific mortality among 74,890 women in the Nurses' Health Study (NHS), 93,054 women in the Nurses' Health Study II, and 40,557 men in the Health Professionals Follow-up Study. Coffee consumption was assessed at baseline using a semiquantitative food frequency questionnaire. During 4,690,072 person-years of follow-up, 19,524 women and 12,432 men died. Consumption of total, caffeinated, and decaffeinated coffee were nonlinearly associated with mortality. Compared with nondrinkers, coffee consumption of 1 to 5 cups per day was associated with lower risk of mortality, whereas coffee consumption of more than 5 cups per day was not associated with risk of mortality. However, when restricting to never smokers compared with nondrinkers, the hazard ratios (and 95% confidence intervals) of mortality were 0.94 (0.89-0.99) for 1.0 or less cup per day, 0.92 (0.87-0.97) for 1.1 to 3.0 cups per day, 0.85 (0.79-0.92) for 3.1 to 5.0 cup per day, and 0.88 (0.78-0.99) for more than 5.0 cup per day (P value for nonlinearity = 0.32; P value for trend < 0.001). Significant inverse associations were observed for caffeinated (P value for trend < 0.001) and decaffeinated coffee (P value for trend = 0.022). Significant inverse associations were observed between coffee consumption and deaths attributed to cardiovascular disease, neurologic diseases, and suicide. No significant association between coffee consumption and total cancer mortality was found.

CONCLUSIONS: Higher consumption of total coffee, caffeinated coffee, and decaffeinated coffee was associated with lower risk of total mortality.


You are not logged in. Sign Up or Log In to join the discussion.


Sort by: Most RecentHighest Rated

Matthew Markert

I'm reminded of the Simpsons episode where Bart tells Homer he should eat the play-doh, reading from the side "It says here it's non-toxic!" Homer, who has already been eating it, turns to him and says "well hey, that's a plus."


Maqsood Ali Mohammad

It's not clear whether the coffee was sweetened or not, if yes then how many teaspoons of sugar was added to a cup of coffee.
Sugar intake itself is associated with increased mortality so it's very important to mention the average sugar content of a cup of coffee.


Gonzalo Corona

Coffee wins this battle, moderate intake has benefits


Jimmy Arevalo

How many people would actually stop drinking coffee should there be any increased risks at all?


Trending Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"