A case of fatal pemphigus vulgaris in association with beta interferon and interleukin-2 therapy

W L Ramseur, F Richards, D B Duggan
Cancer 1989 May 15, 63 (10): 2005-7
Beta interferon (beta-IFN) and interleukin-2 (IL-2) have been utilized in experimental cancer therapy because of their effects on the immune system. We report here a patient treated with IL-2 and beta-IFN who rapidly developed an immune-mediated, bullous exfoliative dermatitis and who ultimately died. Various etiologic mechanisms are proposed.

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