[Novel agents in multiple myeloma treatment]

Shigeki Ito
[Rinshō Ketsueki] the Japanese Journal of Clinical Hematology 2015, 56 (10): 2066-73
The introduction of bortezomib and IMiDs has improved outcomes of patients with multiple myeloma (MM). Moreover, second-generation IMiDs (pomalidomide) have recently been approved in Japan. Due to the incurability of this disease, newer drugs with different mechanisms of action designed to prolong survival and achieve cure are urgently needed. There are novel agents which appear to be promising, such as monoclonal antibodies (elotuzumab, daratumumab), second-generation proteasome inhibitors (carfilzomib), deacethylase inhibitors (panobinostat), and the kinesin protein inhibitor (Arry-520). In the MM-003 trial, there was a significant advantage in the pomalidomide plus dexamethasone arm over high-dose dexamethasone in terms of ORR, PFS, and OS in MM patients who had failed both lenalidomide and bortezomib treatment. In addition, the ASPIRE trial showed carfilzomib in combination with lenalidomide plus dexamethasone to provide a survival advantage over lenalidomide plus dexamethasone for relapsed/refractory MM. These encouraging results indicate that the use of newer agents, alone or in combinations, may overcome double-refractory disease. Other agents such as kinase inhibitors or signaling pathway inhibitors are now under investigation. The use of cocktails of different agents with different mechanisms of action in an earlier stage of the disease may help to obtain durable remissions or even disease cure.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"