Add like
Add dislike
Add to saved papers

Arjunolic acid, a pentacyclic triterpenoidal saponin of Terminalia arjuna bark protects neurons from oxidative stress associated damage in focal cerebral ischemia and reperfusion.

BACKGROUND: Arjunolic acid (AA), a pentacyclic triterpenoidal saponin of Terminalia arjuna is well recognized for its antioxidant properties. We proposed to evaluate its antioxidant potential against focal cerebral ischemia reperfusion (I/R) injury in rats subjected to middle cerebral artery occlusion (MCAO).

METHODS: In the present study, rats were randomly divided into a sham, MCAO, AA (10 and 20mg/kg) treated groups. Rats received their respective treatment orally by gavage for 7 days prior to MCAO. Rats were anaesthetized with ketamine (100mg/kg), xylazine (10mg/kg) and subjected to 2h occlusion and 22h reperfusion. Neurological deficit, brain water content and oxidative stress markers were measured after 22h of reperfusion.

RESULTS: Rats pretreated with AA showed significantly reduced neurological deficit score, infarct size. AA prevented neuronal damage induced by I/R by regulating the levels of malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO), protein carbonyl content and mitochondria generated reactive oxygen species. In addition, it also controlled the enzyme activities of Na(+)-K(+) ATPase, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR).

CONCLUSIONS: Pre-treatment with AA effectively prevented the cerebral I/R induced oxidative damage by virtue of its antioxidant potential. These results indicate that supplementation of AA may be beneficial in stroke prone population.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app