Multifunctional theranostic nanoplatform for cancer combined therapy based on gold nanorods

Wei-Hai Chen, Cai-Xia Yang, Wen-Xiu Qiu, Guo-Feng Luo, Hui-Zhen Jia, Qi Lei, Xiao-Yong Wang, Gang Liu, Ren-Xi Zhuo, Xian-Zheng Zhang
Advanced Healthcare Materials 2015 October 28, 4 (15): 2247-59
Nanomaterials that integrate diagnostic and therapeutic functions within a single nanoplatform promise great advances in revolutionizing cancer therapy. A smart multifunctional theranostic drug-delivery system (DDS) based on gold nanorods (abbreviated as GNR/TSDOX) is designed for cancer-targeted imaging and imaging-guided therapy. In this intelligent theranostic DDS, the active targeting ligand biotin is introduced to track cancer sites in vivo. With the aid of photothermal/photoacoustic imaging, GNR/TSDOX can ablate cancer specifically and effectively. When stimulated with a single near-infrared (NIR) light source, this NIR light energy is effectively absorbed and converted into heat by GNR/TSDOX for localized photothermal therapy and the increase in temperature also further triggers the cascaded release of the anticancer drug for combined thermo-chemotherapy. More importantly, the in vivo cure effect can be well guided by regulating the irradiation time and intensity of the NIR light.

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