MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN

Tao Yu, Lei Liu, Jing Li, Mingxia Yan, Hechun Lin, Ying Liu, Dandan Chu, Hong Tu, Aiqin Gu, Ming Yao
Oncotarget 2015 October 6, 6 (30): 30239-50
MicroRNAs (miRNAs) are involved in human cancer including non-small cell lung cancer (NSCLC). In this study, we compared miRNA expression microarray of SPC-A-1sci (high metastatic) and SPC-A-1 (weakly metastatic) cells. We found that miRNA-10a was up-regulated in NSCLC compared with corresponding normal tissues. High expression of miR-10a was associated with tumor node metastasis and lymph node metastasis. Furthermore, overexpression of miR-10a promoted NSCLC cell proliferation, migration and invasion in vitro. We found that PTEN was a direct target of miR-10a in NSCLC. Also miR-10a activated the PTEN/AKT/ERK pathway. We suggest that miR-10a contributes to NSCLC by targeting PTEN.

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