JOURNAL ARTICLE

Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent

Maria Victória Quaresma, Fred Bernardes Filho, Janaína Hezel, Murilo Calvo Peretti, Bernard Kawa Kac, Luna Azulay-Abulafia
Anais Brasileiros de Dermatologia 2015, 90 (3 Suppl 1): 51-4
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Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids include, among others, dapsone. This drug is not without side effects and its use requires clinical and laboratory control. We present a patient with PV initially managed with suboptimal dose of prednisone, evolving into drug-induced hepatitis after introduction of dapsone.

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