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Reversible Severe Eosinophilic Endomyocardial Fibrosis During Pregnancy: A Case Report

Marc Pineton de Chambrun, Philippe Charron, Danièle Vauthier-Brouzes, Philippe Cluzel, Julien Haroche, Jean-Emmanuel Kahn, Zahir Amoura, Fleur Cohen Aubart
Medicine (Baltimore) 2015, 94 (32): e1307
Idiopathic hypereosinophilic syndrome (HES) is a condition of unknown origin characterized by clinical manifestations attributable to eosinophilia and eosinophilic infiltration of tissues. Cardiac involvement is rare and threatening accounting for 33% to 43% of death in HES. Management of pregnant patients with HES is challenging and have rarely been reported, particularly in the setting of heart failure.We here report on the case of a 29-year-old woman with HES who developed severe endomyocardial fibrosis with heart failure during pregnancy. Outcome was favorable under treatment with prednisone and azathioprine.This case illustrates a favorable outcome of endomyocardial fibrosis during pregnancy.

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