SOST polymorphisms and response to alendronate treatment in postmenopausal Chinese women with osteoporosis

Pei-ran Zhou, Xiao-jie Xu, Zhen-lin Zhang, Er-yuan Liao, De-cai Chen, Jian Liu, Wen Wu, Yan Jiang, Ou Wang, Wei-bo Xia, Xiao-ping Xing, Ling Xu, Mei Li
Pharmacogenomics 2015, 16 (10): 1077-88

AIM: To investigate the association between SOST gene polymorphisms and response to alendronate treatment.

MATERIALS & METHODS: 639 Chinese postmenopausal women with osteoporosis or osteopenia received alendronate treatment. Polymorphisms of SOST were analyzed. Bone mineral density (BMD), serum ALP and β-CTX levels were measured. The correlation of SOST polymorphisms with changes of BMD and bone biomarkers after treatment was analyzed.

RESULTS: rs1234612 and rs851054 polymorphisms were correlated to baseline lumbar spine BMD (p < 0.05). After 12 months of treatment rs1234612 and rs865429 polymorphisms were correlated to BMD changes at the lumbar spine (p < 0.05) or femoral neck (p < 0.05), respectively.

CONCLUSION: The polymorphisms of SOST are genetic factors affecting bone health and response to alendronate in Chinese postmenopausal women.

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