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Covert and Overt Hepatic Encephalopathy: Diagnosis and Management

Kavish R Patidar, Jasmohan S Bajaj
Clinical Gastroenterology and Hepatology 2015, 13 (12): 2048-61
Hepatic encephalopathy (HE) is part of a spectrum of neurocognitive changes in cirrhosis. HE is divided into 2 broad categories based on severity: covert hepatic encephalopathy (CHE) and overt hepatic encephalopathy (OHE). CHE has a significant impact on a patient's quality of life, driving performance, and recently has been associated with increased hospitalizations and death. Likewise, OHE is associated with increased rates of hospitalizations and mortality, and poor quality of life. Given its significant burden on patients, care takers, and the health care system, early diagnosis and management are imperative. In addition, focus also should be directed on patient and family member education on the disease progression and adherence to medications. Treatment strategies include the use of nonabsorbable disaccharides, antibiotics (ie, rifaximin), and, potentially, probiotics. Other therapies currently under further investigation include L-ornithine-L-aspartate, ornithine phenylacetate, glycerol phenylbutyrate, molecular adsorbent recirculating system, and albumin infusion.

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husee jayyose

Hello Drs
My dad has recently sit on Rifaximin 550 mg twice in a day because of HE ,my question is to know what kind of treatment or food should be given to him to reduce the clot(prothrombin )
Note that ,his hospitalisation increase due to increasing the clot not the HE itself


husee jayyose



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