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Journal Article
Research Support, Non-U.S. Gov't
Recreational cocaine use is associated with attenuated latent inhibition.
Addictive Behaviors 2015 November
INTRODUCTION: Evidence has linked chronic cocaine use with various cognitive deficits; however few studies have investigated the effects of recreational (non-dependent) use. The present study aimed to assess whether recreational users show deficits in latent inhibition (LI: a measure of delayed learning of an association between 2 stimuli, one of which has been previously exposed (PE) without consequence and thus deemed irrelevant).
METHODS: Using a quasi-experimental between groups design, recreational cocaine users (n = 21), poly-drug users (n = 17) and drug-naive controls (n = 18) were compared on a LI task. Questionnaires assessing psychological health and drug use were also completed.
RESULTS: There was a statistically significant interaction between condition (PE vs non PE) and group (cocaine, polydrug and control); cocaine users scored lower in the PE condition compared to polydrug users and controls, indicating quicker learning.
CONCLUSIONS: Recreational cocaine users show attenuated LI reflecting reduced ability to filter out irrelevant stimuli enabling faster learning of a PE irrelevant and novel stimuli association. This does not appear to be a result of schizotypy and/or other drug use. Thus even at recreational levels, cocaine use may be sufficient to affect inhibitory attentional processes.
METHODS: Using a quasi-experimental between groups design, recreational cocaine users (n = 21), poly-drug users (n = 17) and drug-naive controls (n = 18) were compared on a LI task. Questionnaires assessing psychological health and drug use were also completed.
RESULTS: There was a statistically significant interaction between condition (PE vs non PE) and group (cocaine, polydrug and control); cocaine users scored lower in the PE condition compared to polydrug users and controls, indicating quicker learning.
CONCLUSIONS: Recreational cocaine users show attenuated LI reflecting reduced ability to filter out irrelevant stimuli enabling faster learning of a PE irrelevant and novel stimuli association. This does not appear to be a result of schizotypy and/or other drug use. Thus even at recreational levels, cocaine use may be sufficient to affect inhibitory attentional processes.
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