We have located links that may give you full text access.
MPV and other inflammatory markers in diagnosing acute appendicitis.
OBJECTIVE: To investigate whether mean platelet volume can be used as an inflammatory marker for the diagnosis of acute appendicitis, and to determine the role, if any, of white blood cell count, C-reactive protein and neutrophil count in this regard.
METHODS: The retrospective study was conducted at Mersin University (MEU) Health Research and Application Center, Emergency Department, Mersin, Turkey, and included medical record of patients having gone appendectomy between April 2012 to July 2013. Based on pathology examination, the cases were grouped as uncomplicated, complicated, and non-appendicitis cases. Preoperative white blood cell, neutrophil, C-reactive protein and mean platelet volume were noted. SPSS 16 was used for statistical analysis.
RESULTS: Records of 275 patients were studied. Overall, 90(32.7%) patients were uncomplicated, 120(43.7%) complicated, and 65(23.6%) were non-appendicitis cases. The first two groups had a significantly higher white blood cell (p=0.001) and neutrophil (p<0.001) counts than the third one. Mean platelet volume levels were not statistically different (p=0.478).The neutrophil count had a sensitivity of 76.19%, specificity of 56.92%, positive predictive value of 85.11%, and negative predictive value of 42.53%; white blod cell count had sensitivity 68.10%, specificity 61.54%, positive predictive value 85.12%, and negative predictive value 37.38%; mean platelet volume level had sensitivity 74.76%, specificity 35.38%, positive predictive value 78.89%, and negative predictive value 30.26%; and C-reactive protein level had sensitivity 84.29%, specificity 30.77%, positive predictive value 79.73%, and negative predictive value 37.74%.
CONCLUSIONS: Elevated white blood cell and neutrophil counts may be used as diagnostic tests in cases of acute appendicitis, while C-reactive protein and mean platelet volume levels were not useful as diagnostic markers.
METHODS: The retrospective study was conducted at Mersin University (MEU) Health Research and Application Center, Emergency Department, Mersin, Turkey, and included medical record of patients having gone appendectomy between April 2012 to July 2013. Based on pathology examination, the cases were grouped as uncomplicated, complicated, and non-appendicitis cases. Preoperative white blood cell, neutrophil, C-reactive protein and mean platelet volume were noted. SPSS 16 was used for statistical analysis.
RESULTS: Records of 275 patients were studied. Overall, 90(32.7%) patients were uncomplicated, 120(43.7%) complicated, and 65(23.6%) were non-appendicitis cases. The first two groups had a significantly higher white blood cell (p=0.001) and neutrophil (p<0.001) counts than the third one. Mean platelet volume levels were not statistically different (p=0.478).The neutrophil count had a sensitivity of 76.19%, specificity of 56.92%, positive predictive value of 85.11%, and negative predictive value of 42.53%; white blod cell count had sensitivity 68.10%, specificity 61.54%, positive predictive value 85.12%, and negative predictive value 37.38%; mean platelet volume level had sensitivity 74.76%, specificity 35.38%, positive predictive value 78.89%, and negative predictive value 30.26%; and C-reactive protein level had sensitivity 84.29%, specificity 30.77%, positive predictive value 79.73%, and negative predictive value 37.74%.
CONCLUSIONS: Elevated white blood cell and neutrophil counts may be used as diagnostic tests in cases of acute appendicitis, while C-reactive protein and mean platelet volume levels were not useful as diagnostic markers.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app