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Nonsteroidal anti-inflammatory drugs for treatment of acute gout

Caroline M P G van Durme, Mihir D Wechalekar, Robert B M Landewé
JAMA: the Journal of the American Medical Association 2015 June 9, 313 (22): 2276-7
26057289

CLINICAL QUESTION: Are nonsteroidal anti-inflammatory drugs (NSAIDs) associated with better outcomes than cyclooxygenase inhibitors, glucocorticoids, IL-1 inhibitors or placebo in the treatment of acute gout?

BOTTOM LINE: NSAIDs are not significantly associated with a difference in pain reduction compared with cyclooxygenase inhibitors and glucocorticoids for treating acute gout. However, NSAIDs are associated with higher rates of adverse events and higher rates of withdrawal due to adverse events compared with cyclooxygenase inhibitors.

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