Front matter.

The pHealth 2015 Conference is the 12th in a series of scientific events bringing together expertise from medical, technological, political, administrative, and social domains, and even from philosophy or linguistics. It opens a new chapter in the success story of the series of international conferences on wearable or implantable micro and nano technologies for personalized medicine by presenting keynotes, invited talks, oral presentations, and short poster presentations provided by close to 100 authors from 20 countries from various parts of the world. Starting in 2003 with personal health management systems, pHealth conferences have evolved to truly interdisciplinary and global events by covering technological and biomedical facilities, legal, ethical, social, and organizational requirements and impacts as well as necessary basic research for enabling future proof care paradigms. Thereby, it combines medical services with public health, prevention, social and elderly care, wellness and personal fitness to establish participatory, predictive, personalized, preventive, and effective care settings. By this way, it has attracted scientists, developers, and practitioners from various technologies, medical and health disciplines, legal affairs, politics, and administration from all over the world. The conference brought together health services vendor and provider institutions, payer organizations, governmental departments, academic institutions, professional bodies, but also patient and citizens representatives. Smart mobile systems such as microsystems, smart textiles, smart implants, sensor-controlled medical devices, and innovative sensor and actuator principles and techniques as well as related body, local and wide area networks up to Cloud services have become important enablers for telemedicine and ubiquitous pervasive health as the next generation health services. Social media and gamification have added even further knowledge to pHealth as an eco-system. OECD has defined four basic areas to be managed in the new care model: address the big data challenges; foster meaningful innovation; understand and address the potential new risks; and support concerted effort to un-silo communities for a virtual care future. The multilateral benefits of pHealth technologies for all stakeholder communities including patients, citizens, health professionals, politicians, healthcare establishments, and companies from the biomedical technology, pharmaceutical, and telecommunications domain gives enormous potential, not only for medical quality improvement and industrial competitiveness, but also for managing health care cost. The pHealth 2015 Conference thankfully benefits from the experience and the lessons learned from the organizing committees of previous pHealth events, particularly 2009 in Oslo, 2010 in Berlin, 2011 in Lyon, 2012 in Porto, 2013 in Tallinn, and 2014 Vienna. The 2009 conference brought up the interesting idea of having special sessions, focusing on a particular topic, and being organized by a mentor/moderator. The Berlin event in 2010 initiated workshops on particular topics prior to the official kick-off of the conference. Lyon in 2011 initiated the launch of socalled dynamic demonstrations allowing the participants to dynamically show software and hardware solutions on the fly without needing a booth. Implementing preconference events, the pHealth 2012 in Porto gave attendees a platform for presenting and discussing recent developments and provocative ideas that helped to animate the sessions. Highlight of pHealth 2013 in Tallinn was the special session on European projects' success stories, but also presentations on the newest paradigm changes and challenges coming up with Big Data, Analytics, Translational and Nano Medicine, etc. Vienna in 2014 focused on lessons learned from international and national R&D activities and practical solutions, and especially from the new EU Framework Program for Research and Innovation, Horizon 2020. Beside reports about technology transfer support and building ecosystems and value chains to ensure better time to market and higher impact of knowledge-based technologies, the acceptability of solutions, especially considering security and privacy aspects have been presented and deeply discussed. The pHealth 2015 Conference addresses mobile technologies, knowledge-driven applications and computer-assisted decision support, but also apps designed to support elderly as well as chronic patients in their daily and possibly independent living. Invited contributions consider fundamental scientific and methodological challenges of adaptive, autonomous, and intelligent pHealth approaches, the new role of patients as consumers and active party with growing autonomy and related responsibilities, but also requirements and solutions for mHealth in low- and medium income countries. It aims at sharing experiences and results, and opening up for the future. The pHealth 2015 presentations are complemented by demonstrations of practical artifacts and solutions as well as by a students' poster competition. More insights in the pHealth challenge are provided by a Satellite Conference of NovaMedTech. Embedded Sensor Systems for Health, NovaMedTech, and HL7 Sweden, but - following a long-term tradition - also the Working Groups "Electronic Health Records (EHR)", "Personal Portable Devices (PPD)" and "Security, Safety and Ethics (SSE)" of the European Federation for Medical Informatics (EFMI) have been actively involved in the preparation and realization of the pHealth 2015 Conference. This proceedings volume covers 3 keynotes and 2 specially invited talks, but also 23 oral presentations selected from more than 50 submissions to the pHealth 2015 conference, and 8 poster presentations. All submissions have been carefully and critically reviewed by at least two independent experts from other than the authors' home countries, and additionally by at least one member of the Scientific Program Committee. The performed highly selective review process resulted in a full papers rejection rate of more than 50%, thereby guaranteeing a high scientific level of the accepted and finally published papers. The editors are indebted to the acknowledged and highly experienced reviewers for having essentially contributed to the quality of the conference and the book at hand. Both the pHealth 2015 Conference and the publication of the pHealth 2015 proceedings at IOS Press would not have been possible without the supporters and sponsors Health Level 7 International (HL7 International), Embedded Sensor Systems for Health, NovaMedTech, and European Federation for Medical Informatics (EFMI). The editors are also grateful to the dedicated efforts of the Local Organizing Committee members and their supporters for carefully and smoothly preparing and operating the conference. They especially thank all team members from the School of Innovation, Design and Engineering, Mälardalen University, Västerås, Sweden, for their dedication to the event. Bernd Blobel, Maria Lindén, Mobyen Uddin Ahmed (Editors).