Activity of Krebs cycle enzymes in mdx mice

Clarissa M Comim, Andreza Hoepers, Letícia Ventura, Viviane Freiberger, Diogo Dominguini, Francielle Mina, Bruna P Mendonça, Giselli Scaini, Mariz Vainzof, Emílio L Streck, João Quevedo
Muscle & Nerve 2016, 53 (1): 91-5

INTRODUCTION: Duchenne muscular dystrophy (DMD) is a degenerative disease of skeletal, respiratory, and cardiac muscles caused by defects in the dystrophin gene. More recently, brain involvement has been verified. Mitochondrial dysfunction and oxidative stress may underlie the pathophysiology of DMD. In this study we evaluate Krebs cycle enzymes activity in the cerebral cortex, diaphragm, and quadriceps muscles of mdx mice.

METHODS: Cortex, diaphragm, and quadriceps tissues from male dystrophic mdx and control mice were used.

RESULTS: We observed increased malate dehydrogenase activity in the cortex; increased malate dehydrogenase and succinate dehydrogenase activities in the diaphragm; and increased citrate synthase, isocitrate dehydrogenase, and malate dehydrogenase activities in the quadriceps of mdx mice.

CONCLUSION: This study showed increased activity of Krebs cycle enzymes in cortex, quadriceps, and diaphragm in mdx mice.

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