Calciphylaxis: risk factors, diagnosis, and treatment

Sagar U Nigwekar, Daniela Kroshinsky, Rosalynn M Nazarian, Jeremy Goverman, Rajeev Malhotra, Vicki Ann Jackson, Mihir M Kamdar, David J R Steele, Ravi I Thadhani
American Journal of Kidney Diseases 2015, 66 (1): 133-46
Calciphylaxis is a rare but devastating condition that has continued to challenge the medical community since its early descriptions in the scientific literature many decades ago. It is predominantly seen in patients with chronic kidney failure treated with dialysis (uremic calciphylaxis) but is also described in patients with earlier stages of chronic kidney disease and with normal kidney function. In this review, we discuss the available medical literature regarding risk factors, diagnosis, and treatment of both uremic and nonuremic calciphylaxis. High-quality evidence for the evaluation and management of calciphylaxis is lacking at this time due to its rare incidence and poorly understood pathogenesis and the relative paucity of collaborative research efforts. We hereby provide a summary of recommendations developed by a multidisciplinary team for patients with calciphylaxis.

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Isabel Cristina Renteria Silva

Importante tema. Cada vez más frecuente en pacientes uremicos


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