Cutaneous manifestations of vemurafenib therapy for metastatic melanoma

Joshua L Owen, Isha E Lopez, Seemal R Desai
Journal of Drugs in Dermatology: JDD 2015, 14 (5): 509-10
Vemurafenib, a BRAF inhibitor, is FDA-approved for the treatment of metastatic melanoma in patients who harbor the BRAF V600E mutation. By inhibiting BRAF, vemurafenib prevents the mitogen-activated protein kinase (MAPK) pathway from driving melanoma growth. Here we present a patient with paradoxical activation of the MAPK pathway by vemurafenib, ultimately resulting in deleterious cutaneous manifestations. An emphasis on close follow-up is warranted for new or changing lesions for patients on this medication and other BRAF inhibitors.

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