Chimeric antigen receptor engineering: a right step in the evolution of adoptive cellular immunotherapy

Jose A Figueroa, Adair Reidy, Leonardo Mirandola, Kayley Trotter, Natallia Suvorava, Alejandro Figueroa, Venu Konala, Amardeep Aulakh, Lauren Littlefield, Fabio Grizzi, Rakhshanda Layeequr Rahman, Marjorie R Jenkins, Breeanna Musgrove, Saba Radhi, Nicholas D'Cunha, Luke N D'Cunha, Paul L Hermonat, Everardo Cobos, Maurizio Chiriva-Internati
International Reviews of Immunology 2015, 34 (2): 154-87
Cancer immunotherapy comprises different therapeutic strategies that exploit the use of distinct components of the immune system, with the common goal of specifically targeting and eradicating neoplastic cells. These varied approaches include the use of specific monoclonal antibodies, checkpoint inhibitors, cytokines, therapeutic cancer vaccines and cellular anticancer strategies such as activated dendritic cell (DC) vaccines, tumor-infiltrating lymphocytes (TILs) and, more recently, genetically engineered T cells. Each one of these approaches has demonstrated promise, but their generalized success has been hindered by the paucity of specific tumor targets resulting in suboptimal tumor responses and unpredictable toxicities. This review will concentrate on recent advances on the use of engineered T cells for adoptive cellular immunotherapy (ACI) in cancer.

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