Multiple cyp51A-based mechanisms identified in azole-resistant isolates of Aspergillus fumigatus from China

Musang Liu, Rong Zeng, Lili Zhang, Dongmei Li, Guixia Lv, Yongnian Shen, Hailin Zheng, Qiangqiang Zhang, Jingjun Zhao, Nan Zheng, Weida Liu
Antimicrobial Agents and Chemotherapy 2015, 59 (7): 4321-5
Seventy-two A. fumigatus clinical isolates from China were investigated for azole resistance based on mutations of cyp51A. We identified four azole-resistant strains, among which we found three strains highly resistant to itraconazole, two of which exhibit the TR34/L98H/S297T/F495I mutation, while one carries only the TR34/L98H mutation. To our knowledge, the latter has not been found previously in China. The fourth multiazole-resistant isolate (with only moderate itraconazole resistance) carries a new G432A mutation.

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