JOURNAL ARTICLE

ACG Clinical Guideline: Primary Sclerosing Cholangitis

Keith D Lindor, Kris V Kowdley, M Edwyn Harrison
American Journal of Gastroenterology 2015, 110 (5): 646-59; quiz 660
25869391
Primary sclerosing cholangitis is a chronic cholestatic liver disease that can shorten life and may require liver transplantation. The cause is unknown, although it is commonly associated with colitis. There is no approved or proven therapy, although ursodeoxycholic acid is used by many on an empiric basis. Complications including portal hypertension, fat-soluble vitamin deficiency, metabolic bone diseases, and development of cancers of the bile duct or colon can occur.

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Joseph Martin

What is the median life expectancy of patients with PSC?

What are the criteria for liver transplant and what percentage of pts. require it?

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