[302-POS]: Cardiovascular disease in a pregnant woman's partner as a risk factor for preeclampsia.

OBJECTIVES: Assessing risk of developing a hypertensive disorder of pregnancy (HDP) in nulliparous women is imprecise. Previous evidence suggests that self-reported family history of cardiovascular disease and risk (in particular risk in the woman's father) may improve identification of preeclampsia (Parker, ISOM 2012). The aim of this study was to evaluate maternal report of paternal family history of cardiovascular disease (CVD) or risk (CVR) as a risk factor for HDP including preeclampsia.

METHODS: Women were recruited prospectively and reported on cardiovascular health in themselves, their partners and first degree relatives (n=997). HDP diagnoses were assigned using SOMANZ (2008) criteria.

RESULTS: Preeclampsia was diagnosed in 12.6% of women, gestational hypertension in 6.2%. CVD/CVR was reported by 22.3% of mothers (1.7% CVD alone) and 9.3% of partners (1.7% CVD alone). Median age of the women was 27 years (range 16-45), median age of the partners was 30 years (range 26-34). All partners with CVD were under 45 years old (median 32, range 24-39). The median age of men with risk alone was 33 years (range 29-38). Partners' CVD increased risk of preeclampsia (5.6% vs. 1.7%; OR=5.07, 95% CI 1.72-14.94, p=.003) adjusted for maternal age, BMI, smoking and maternal CVD/CVR. No increase in risk of gestational hypertension was evident. Partners' CVR did not appear to increase risk of HDP.

CONCLUSIONS: History of CVD in the woman's partner may indicate elevated risk of preeclampsia however, the low frequency of CVD in partners at this young age impacts on the sample size and should be examined in future research.

DISCLOSURES: C.E. Parker: None. D.A. Doherty: None. B.N. Walters: None.