Correlation of the plasma levels of soluble RAGE and endogenous secretory RAGE with oxidative stress in pre-diabetic patients

Minglian Huang, Yanyan Que, Xingping Shen
Journal of Diabetes and its Complications 2015, 29 (3): 422-6

BACKGROUND: Soluble RAGE (sRAGE), endogenous secretory RAGE (esRAGE) and oxidative stress played important roles in the pathogenesis of diabetes and its complications. The changes in sRAGE and esRAGE during pre-diabetes were indefinite.

METHODS: Patients were divided into NGT, pre-diabetes (pre-DM), and newly diagnosed diabetes mellitus (DM) groups according to blood glucose levels. The levels of sRAGE, esRAGE, 8-isoprostaglandin F2α (8-iso-PGF2α), superoxide dismutase (SOD) activity, total antioxidant capacity (TAOC), malondialdehyde (MDA), and other related indicators were then assessed.

RESULTS: sRAGE and esRAGE in the pre-DM and DM groups were significantly lower than in the NGT group (p<0.05). In the pre-DM group, sRAGE was positively correlated with esRAGE (r=0.382, P=0.007), and negatively correlated with homeostasis model assessment-estimated insulin resistance (HOMA-IR), MDA, and 8-iso-PGF2α (r=-0.314, -0.313, and -0.34, P=0.028, 0.028, and 0.016, respectively). The concentration of esRAGE was positively correlated with sRAGE and TAOC (r=0.382 and 0.598, and P=0.007, <0.001), and negatively correlated with MDA (r=-0.397, P=0.005).

CONCLUSIONS: Changes in sRAGE, esRAGE, and oxidative stress occurred in pre-diabetic patients. sRAGE and esRAGE might play an essential role in the balance between oxidative stress and antioxidant defense.

THE SIGNIFICANT FINDINGS OF THE STUDY: Changes in sRAGE, esRAGE, and oxidative stress occurred in pre-diabetic patients. THIS STUDY ADDS: sRAGE, esRAGE, and oxidative stress are altered early during pre-diabetes. sRAGE and esRAGE may have played different roles in the balance between oxidative stress and the antioxidant defense.

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