Imaging as an Outcome Measure in Gout Studies: Report from the OMERACT Gout Working Group

Rebecca Grainger, Nicola Dalbeth, Helen Keen, Laura Durcan, N Lawrence Edwards, Fernando Perez-Ruiz, Cesar Diaz-Torne, Jasvinder A Singh, Dinesh Khanna, Lee S Simon, William J Taylor
Journal of Rheumatology 2015, 42 (12): 2460-4

OBJECTIVE: The gout working group at the Outcome Measures in Rheumatology (OMERACT) 12 meeting in 2014 aimed to determine which imaging modalities show the most promise for use as measurement instruments for outcomes in studies of people with chronic gout and to identify the key foci for future research about the performance of these imaging techniques with respect to the OMERACT filter 2.0.

METHODS: During the gout session, a systematic literature review of the data addressing imaging modalities including plain radiography (XR), conventional computed tomography (CT), dual-energy computed tomography (DECT), magnetic resonance imaging (MRI), and ultrasound (US) and the fulfillment of the OMERACT filter 2.0 was presented.

RESULTS: The working group identified 3 relevant domains for imaging in gout studies: urate deposition (tophus burden), joint inflammation, and structural joint damage.

CONCLUSION: The working group prioritized gaps in the data and identified a research agenda.

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