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JOURNAL ARTICLE
Monocytes compensate Kupffer cell loss during bacterial infection.
Immunity 2015 January 21
Liver Kupffer cells (KCs) are self-maintained tissue-resident macrophages. In this issue of Immunity, Blériot et al. demonstrate that bacterial infection leads to KC necroptosis and quantitative replacement by monocyte-derived macrophages that contribute to antibacterial immunity and restoration of tissue integrity.
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