Prevalence of Scedosporium species and Lomentospora prolificans in patients with cystic fibrosis in a multicenter trial by use of a selective medium

L Sedlacek, B Graf, C Schwarz, F Albert, S Peter, B Würstl, S Wagner, M Klotz, A Becker, G Haase, G Laniado, B Kahl, S Suerbaum, M Seibold, K Tintelnot
Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society 2015, 14 (2): 237-41

OBJECTIVE: Detection of hyphomycetes of the Scedosporium apiospermum complex and Lomentospora prolificans (Sac-Lp) is not yet standardized. Prevalence rates in patients with cystic fibrosis (CF) and the resistance pattern of these pathogens in Germany are unknown.

METHODS: In a one-year prospective study 11 laboratories used a selective medium for isolation of Sac-Lp, examining >11,600 respiratory samples from 2346 patients with CF. Isolates were identified by molecular methods and tested for susceptibility to antifungal drugs.

RESULTS: The prevalence of Sac-Lp in patients with CF in Germany varied from 0.0 to 10.5% (mean: 3.1%) among the clinical centres. The benefit of the selective medium SceSel(+) compared to standard media for fungi was documented for >5000 samples. High antifungal resistance was detected in the S. apiospermum complex, and the multiresistance of L. prolificans was confirmed.

CONCLUSION: Microbiology laboratories should be aware of these resistant species in patients with CF and consider using a selective medium.

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