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Neostigmine for acute colonic pseudo-obstruction: A meta-analysis.

Raul Guillermo Lopez Valle, Francisco Lopez Godoy
Annals of Medicine and Surgery 2014 September
INTRODUCTION: Acute colonic pseudo-obstruction (ACPO) is an uncommon condition that occasionally develops in hospitalized patients with serious underlying ailments. Its early recognition is essential to reduce life-threatening complications. Few low-powered randomized clinical trials (RCTs) have confirmed the effectiveness of neostigmine for treatment.

AIM: To analyse the effectiveness and main side effects of neostigmine in the treatment of ACPO.

EXPERIMENTAL: A literature search was performed for all published RCTs, reporting on neostigmine as treatment for ACPO.

RESULTS: Four studies fulfilled the inclusion criteria, evaluating 127 patients: treatment group = 65, control group = 62. Neostigmine effectiveness to resolve ACPO with only one dose was 89.2% versus 14.65% (P < 0.001, NNT = 1 [95% CI 1-2]).

CONCLUSIONS: Neostigmine is a safe and effective option for patients with ACPO who failed to respond to conservative management.

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