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JOURNAL ARTICLE

Comparison of erythromycin ethylsuccinate and co-trimoxazole for treatment of pertussis

J E Hoppe, U Halm, H J Hagedorn, A Kraminer-Hagedorn
Infection 1989, 17 (4): 227-31
2548964
Fifty-five ambulatory children with early culture-proven pertussis were treated for two weeks either with erythromycin ethylsuccinate (n = 28) (50-80 mg/kg/day in three doses during meals) or with co-trimoxazole (n = 27) (6-10 mg trimethoprim/kg/day in two doses after meals). After completion of treatment, all patients in the erythromycin group were culture-negative, while in the co-trimoxazole group one child was still culture-positive. In this case vomiting may have played a role. Both agents appear to be able to eradicate Bordetella pertussis from the nasopharynx of patients with early whooping cough.

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