Gene dynamics of core transcription factors for pluripotency in embryonic stem cells

Brit G David, Kazuko Okamoto, Taishi Kakizuka, Taro Ichimura, Tomonobu M Watanabe, Hideaki Fujita
Journal of Bioscience and Bioengineering 2015, 119 (4): 406-9
Embryonic stem cell (ESC) pluripotency is maintained by core transcription factors (TFs). Although the expression of these TFs is well documented, their expression dynamics is poorly evaluated. Here, we visualized the dynamics of Nanog and Oct3/4 expression in ESC using fluorescent reporters and found that expression of these TFs change dramatically during culture.

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