JOURNAL ARTICLE

Factors affecting nebulised medicine adherence in adult patients with cystic fibrosis: a qualitative study

Alice Hogan, Mary-Ann Bonney, Jo-Anne Brien, Rita Karamy, Parisa Aslani
International Journal of Clinical Pharmacy 2015, 37 (1): 86-93
25432693

BACKGROUND: Nebulised medicines contribute to the high treatment burden experienced by patients with cystic fibrosis (CF).

OBJECTIVES: This study explored experiences of adult patients with CF when using nebulised medicines, factors impacting on their adherence to nebulised therapy and strategies they used to facilitate adherence.

SETTING: Community setting, in Sydney, Australia.

METHODS: Ten patients with CF were recruited through a CF patient organisation. Semi-structured face-to-face interviews were conducted, addressing the study objectives. Interviews were audio-recorded, transcribed verbatim and content analysed for anticipated and emergent themes.

MAIN OUTCOME MEASURE: Experiences with using nebulised medicines; and barriers and facilitators of adherence to nebulised medicines.

RESULTS: Participants' age ranged from 22 to 45 years, with half being male. Four broad themes (with more specific sub-themes) were identified from the interviews: experiences with using nebulised medicines (cleaning nebuliser, time taken to use nebuliser medicine, flexibility in use of nebuliser); feelings about using nebulised medicines (necessary/important, dislike, part of life); factors impacting non-adherence (time consuming therapy, side effects/effects of medicine, work/social demands, lack of perceived importance); factors and strategies facilitating adherence (perceived medicine importance, habit/routine, support, health benefits, technology/medicine dose form, timetabling).

CONCLUSIONS: Nebulised therapy for cystic fibrosis patients takes a substantial amount of time, with patients trying to alter their routine to incorporate nebulising into their daily lives. However there are still many factors that lead to low adherence, including work/social demands and travelling. Patients balance the necessity for nebulised therapy against the barriers, and engage in intentional non-adherence at times. Future strategies and resources should target and address specific factors identified by patients with CF as being important and impacting their adherence to nebulised medicines.

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