JOURNAL ARTICLE
REVIEW

Diagnosis and subclassification of acute lymphoblastic leukemia

Sabina Chiaretti, Gina Zini, Renato Bassan
Mediterranean Journal of Hematology and Infectious Diseases 2014, 6 (1): e2014073
25408859
Acute lymphoblastic leukemia (ALL) is a disseminated malignancy of B- or T-lymphoblasts which imposes a rapid and accurate diagnostic process to support an optimal risk-oriented therapy and thus increase the curability rate. The need for a precise diagnostic algorithm is underlined by the awareness that both ALL therapy and related success rates may vary greatly between ALL subsets, from standard chemotherapy in patients with standard-risk ALL, to allotransplantation (SCT) and targeted therapy in high-risk patients and cases expressing suitable biological targets, respectively. This review summarizes how best to identify ALL and the most relevant ALL subsets.

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