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The potential usefulness of (18)F-FDG PET/CT for detecting colorectal carcinoma and adenoma in asymptomatic adults.
Annals of Nuclear Medicine 2015 Februrary
OBJECTIVE: The aim of this study was to evaluate the potential usefulness of (18)F-FDG PET/CT for detecting colorectal carcinoma and adenoma in asymptomatic adults.
METHODS: 614 subjects were enrolled in this retrospective study. They underwent both (18)F-FDG PET/CT and colonoscopy in the same day as part of a cancer-screening program. Small focal FDG accumulation along the colorectum on (18)F-FDG PET/CT images were compared with colonoscopy findings. Size of lesion was measured on colonoscopy and histology was determined by biopsy or polypectomy.
RESULTS: In 614 (18)F-FDG PET/CT images, 27 foci of FDG uptakes were observed in the colorectal area in 25 subjects. The overall sensitivity and specificity of (18)F-FDG PET/CT were 5.6 and 96.8 %, respectively, but sensitivity to detect lesions larger than or equal to 1 cm was 25.8 %. On the ROC analysis, the optimal cut-off value for differentiating premalignant and malignant lesions from other benign conditions was 5.0 (sensitivity = 50 %, specificity = 88 %, AUC = 0.643).
CONCLUSIONS: Colonoscopic evaluation could be recommended by presence of focal colonic FDG uptake on (18)F-FDG PET/CT, especially when SUVmax is over 5.
METHODS: 614 subjects were enrolled in this retrospective study. They underwent both (18)F-FDG PET/CT and colonoscopy in the same day as part of a cancer-screening program. Small focal FDG accumulation along the colorectum on (18)F-FDG PET/CT images were compared with colonoscopy findings. Size of lesion was measured on colonoscopy and histology was determined by biopsy or polypectomy.
RESULTS: In 614 (18)F-FDG PET/CT images, 27 foci of FDG uptakes were observed in the colorectal area in 25 subjects. The overall sensitivity and specificity of (18)F-FDG PET/CT were 5.6 and 96.8 %, respectively, but sensitivity to detect lesions larger than or equal to 1 cm was 25.8 %. On the ROC analysis, the optimal cut-off value for differentiating premalignant and malignant lesions from other benign conditions was 5.0 (sensitivity = 50 %, specificity = 88 %, AUC = 0.643).
CONCLUSIONS: Colonoscopic evaluation could be recommended by presence of focal colonic FDG uptake on (18)F-FDG PET/CT, especially when SUVmax is over 5.
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