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Case Reports
Journal Article
Review
Trichodysplasia spinulosa: rare presentation of polyomavirus infection in immunocompromised patients.
Journal of Cutaneous Medicine and Surgery 2014 November
BACKGROUND: Trichodysplasia spinulosa (TS) is a rare, striking, folliculocentric papular eruption seen exclusively in immunosuppressed patients. The eruption can be disfiguring, associated with leonine faces and alopecia. TS is caused by a polyomavirus, identified as trichodysplasia spinulosa polyomavirus (TSPyV). Few reports exist in the literature, and support for treatment options is sparse.
METHOD AND RESULTS: We report a patient with TS with underlying lupus nephropathy and renal transplant-associated immunosuppression. Diagnosis was confirmed by biopsy and pathognomonic histologic findings in the context of her extensive, spiculated monomorphous papules. With a biopsy-confirmed diagnosis, oral valganciclovir was prescribed, and the patient showed marked skin texture improvement and hair regrowth.
CONCLUSION: The continued reporting of cases of TS will improve clinical identification of this condition and provide better information regarding treatment and long-term consequences.
METHOD AND RESULTS: We report a patient with TS with underlying lupus nephropathy and renal transplant-associated immunosuppression. Diagnosis was confirmed by biopsy and pathognomonic histologic findings in the context of her extensive, spiculated monomorphous papules. With a biopsy-confirmed diagnosis, oral valganciclovir was prescribed, and the patient showed marked skin texture improvement and hair regrowth.
CONCLUSION: The continued reporting of cases of TS will improve clinical identification of this condition and provide better information regarding treatment and long-term consequences.
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