Certolizumab Pegol, a New Anti-TNF-α in the Armamentarium against Ocular Inflammation

Victor Llorenç, Marina Mesquida, Maite Sainz de la Maza, Ricardo Blanco, Vanesa Calvo, Olga Maíz, Ana Blanco, Juan Ramón de Dios-Jiménez de Aberásturi, Alfredo Adán
Ocular Immunology and Inflammation 2016, 24 (2): 167-72

PURPOSE: To study the efficacy and tolerance of certolizumab pegol (CZP) in active uveitis.

METHODS: Retrospective case series at 4 referral centers. Patients treated with CZP for active uveitis during at least 6 months were eligible. Inflammation by SUN scores, visual acuity (VA) (logMAR), and central macular thickness (CMT) were compared from baseline until final follow-up. Quiescence was defined as 0+ to 0.5+ in anterior chamber and vitreous haze scores and no CMT increase.

RESULTS: Four males and 3 females (14 eyes) were included, mean age 42.4 ± 8.8 years. All were long-lasting chronic-relapsing uveitis with prior failure to other anti-TNF-α. After a mean follow-up of 10.4 ± 4.8 months, 5/7 patients (71.4%) achieved quiescence with CZP. VA improved significantly from +0.52 ± 0.68 to +0.45 ± 0.68 (p = 0.032) at 1 month and to +0.44 ± 0.64 (p = 0.035) at 6 months. No adverse events were found.

CONCLUSION: CZP can be an effective alternative in refractory uveitis.

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