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Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine.

Crispin Hiley, Elza C de Bruin, Nicholas McGranahan, Charles Swanton
Genome Biology 2014 August 28
The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.

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