JOURNAL ARTICLE
REVIEW

Optimal pig donor selection in islet xenotransplantation: current status and future perspectives

Hai-tao Zhu, Liang Yu, Yi Lyu, Bo Wang
Journal of Zhejiang University. Science. B 2014, 15 (8): 681-91
25091986
Islet transplantation is an attractive treatment of type 1 diabetes mellitus. Xenotransplantation, using the pig as a donor, offers the possibility of an unlimited supply of islet grafts. Published studies demonstrated that pig islets could function in diabetic primates for a long time (>6 months). However, pig-islet xenotransplantation must overcome the selection of an optimal pig donor to obtain an adequate supply of islets with high-quality, to reduce xeno-antigenicity of islet and prolong xenograft survival, and to translate experimental findings into clinical application. This review discusses the suitable pig donor for islet xenotransplantation in terms of pig age, strain, structure/function of islet, and genetically modified pig.

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