Benign neoplasm of the heart increases the risk of first ischemic stroke: a population-based cohort study

Ming-May Lai, Tsai-Chung Li, Cheng-Li Lin, Fung-Chang Sung, Cheng-Chieh Lin, Chiu-Shong Liu, Chia-Hung Kao
International Journal of Stroke: Official Journal of the International Stroke Society 2015, 10 (2): 202-6

OBJECTIVE: The study aims to investigate the incidence of first ischemic stroke in patients with benign cardiac tumors who did or did not undergo operations.

METHODS: We used the National Health Insurance Research Database of Taiwan to conduct the research. The exposure cohort comprised 587 adult patients with benign cardiac tumors. Each patient was randomly frequency matched by age, index month, and index year with 10 participants from the general population who exhibited no history of benign cardiac tumors before the index date (control group). Cox's proportion hazard regression analyses were conducted to determine the relation between benign cardiac tumors and the risk of ischemic stroke.

RESULTS: Based on clinical diagnoses, the prevalence of benign cardiac tumors was 0.004%. Patients with benign cardiac tumors exhibited an increased risk of first ischemic stroke [adjusted hazard ratio: 1.77; (95% confidence interval, 1.20-2.63)], particularly at young ages (adjusted hazard ratio: 22.9, 95% confidence interval: 4.17-126.0). We observed no significant difference in the risk of ischemic stroke between men with and without benign cardiac tumors (adjusted hazard ratio: 1.29, 95% confidence interval: 0.63-2.63). Among patients with benign cardiac tumors, the adjusted hazard ratio of first ischemic stroke was 0.48 (95% confidence interval: 0.23-1.04) in the operation group compared with the nonoperation group.

CONCLUSION: Younger patients (<50 years) with benign cardiac tumors exhibit an increased risk of first ischemic stroke.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.