Bradycardia is associated with future cardiovascular diseases and death in men from the general population

Shinji Makita, Toshiyuki Onoda, Masaki Ohsawa, Kozo Tanno, Fumitaka Tanaka, Shinichi Omama, Yuki Yoshida, Yasuhiro Ishibashi, Kazuyoshi Itai, Kiyomi Sakata, Mutsuko Ohta, Toru Kuribayashi, Kuniaki Ogasawara, Akira Ogawa, Akira Okayama, Motoyuki Nakamura
Atherosclerosis 2014, 236 (1): 116-20

BACKGROUND: Although a higher heart rate is known to be a risk factor for cardiovascular disease (CVD) events, there have been no reports concerning bradycardia. Whether lower and higher resting pulse rates (RPRs) are associated with cardiovascular risk was investigated in subjects from a community-based, prospective cohort study.

METHODS: After subjects with atrial fibrillation, subjects with a history of CVD, and subjects receiving antihypertensive treatment were excluded, 17,766 subjects (5958 men), aged 40-79 (mean 61.5) years, were analyzed. The RPR at baseline was categorized into four groups (RPR<60, 60-69.5, 70-79.5, ≥80 beats per minute (bpm)) using the average value of two consecutive measurements. The endpoint was set as the composite outcome of myocardial infarction, stroke, or sudden death.

RESULTS: During a mean follow-up of 5.6 years, there were 213 events in men and 186 events in women. In Cox regression models, increased risks of CVD were found in the men group with RPR<60 bpm, as well as the group with RPR≥80 bpm, compared with the reference group with RPR 60-69.5 bpm (hazard ratio [HR] = 1.73, p = 0.005 and HR = 2.01, p < 0.001). These increased risks were found even when adjusted for age and other CVD risk factors (HR = 1.55, p = 0.026 with RPR<60 bpm and HR = 1.72, p = 0.009 with RPR≥80 bpm). In women, there were no significant associations between RPR and CVD risk.

CONCLUSION: Bradycardia, as well as a higher pulse rate, may be an independent risk factor for future cardiovascular events in apparently healthy men.

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