JOURNAL ARTICLE
REVIEW

Interleukin-6 in renal disease and therapy

Simon A Jones, Donald J Fraser, Ceri A Fielding, Gareth W Jones
Nephrology, Dialysis, Transplantation 2015, 30 (4): 564-74
25011387
Interleukin (IL)-6 has become a major target for clinical intervention in various autoimmune conditions. Here, drugs including the humanized anti-IL-6 receptor (IL-6R) antibody tocilizumab emphasize the clinical importance of IL-6 in driving disease and poor patient outcomes. During the course of this review, we will outline the biology surrounding IL-6 and discuss the impact of IL-6 in renal disease and the clinical complications associated with renal replacement therapies and transplantation. We will also consider the merit of IL-6 measurement as a prognostic indicator and provide a clinical perspective on IL-6-blocking therapies in renal disease.

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