We have located links that may give you full text access.
Journal Article
Research Support, Non-U.S. Gov't
IL-2 inhibited the generation of CD4+ memory T cells.
Cell Biochemistry and Biophysics 2014 December
The survival of T cells at different stages of development is dependent on extrinsic signals. IL-7 is necessary for the development of memory T cells. IL-7 could induce and maintain the differentiation, survival, and proliferation of CD4(+) memory T cells, and the roles of IL-2 and IL-15 in the generation of CD4(+) memory T cells were still unclear. A CD4(+) memory T cells in vitro generated system by adding IL-7. The phenotype of CD4(+) memory T cells was identified by FACS. The cells proliferation was analyzed by CFSE staining. The involved signal pathways were analyzed by Western blot. We found that IL-2, not IL-15, could inhibit CD4(+) memory T cells generation. Western blot showed that IL-7 up-regulated the P-STAT5A expression and down-regulated Bax expression, IL-2 reduced the effect of IL-7. Besides, IL-2-combined IL-7 up-regulated the P-AKT and Foxo3a expression a little. In conclusion, our data revealed the inhibitory role of IL-2 in CD4(+) memory T cells generation and indicated that PI3K/AKT signal pathway was involved.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app