JOURNAL ARTICLE

In vivo optically encoded photoacoustic flowgraphy

Ruiying Zhang, Lidai Wang, Junjie Yao, Cheng-Hung Yeh, Lihong V Wang
Optics Letters 2014 July 1, 39 (13): 3814-7
24978744
We present an optically encoded photoacoustic (PA) flow imaging method based on optical-resolution PA microscopy. An intensity-modulated continuous-wave laser photothermally encodes the flowing medium, and a pulsed laser generates PA waves to image the encoded heat pattern. Flow speeds can be calculated by cross correlation. The method was validated in phantoms at flow speeds ranging from 0.23 to 11  mm/s. Venous blood flow speed in a mouse ear was also measured.

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